A precursor-inducible zebrafish model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress

Protoporphyria is a metabolic disease that causes excess production of protoporphyrin IX (PP-IX), the final biosynthetic precursor to heme. Hepatic PP-IX accumulation may lead to end-stage liver disease. We tested the hypothesis that systemic administration of porphyrin precursors to zebrafish larva...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:FASEB J
Egile Nagusiak: Elenbaas, Jared S., Maitra, Dhiman, Liu, Yang, Lentz, Stephen I., Nelson, Bradley, Hoenerhoff, Mark J., Shavit, Jordan A., Omary, M. Bishr
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Federation of American Societies for Experimental Biology 2016
Gaiak:
Research Communication
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4836371/
https://ncbi.nlm.nih.gov/pubmed/26839379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201500111R
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