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A precursor-inducible zebrafish model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress
Protoporphyria is a metabolic disease that causes excess production of protoporphyrin IX (PP-IX), the final biosynthetic precursor to heme. Hepatic PP-IX accumulation may lead to end-stage liver disease. We tested the hypothesis that systemic administration of porphyrin precursors to zebrafish larva...
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| Publicado no: | FASEB J |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Federation of American Societies for Experimental Biology
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4836371/ https://ncbi.nlm.nih.gov/pubmed/26839379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201500111R |
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