Identification of the Flavonoid Luteolin as a Repressor of the Transcription Factor Hepatocyte Nuclear Factor 4α

Hepatocyte nuclear factor 4α (HNF4α) is a nuclear receptor that regulates the expression of genes involved in the secretion of apolipoprotein B (apoB)-containing lipoproteins and in glucose metabolism. In the present study, we identified a naturally occurring flavonoid, luteolin, as a repressor of H...

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Vydáno v:J Biol Chem
Hlavní autoři: Li, Juan, Inoue, Jun, Choi, Jung-Min, Nakamura, Shugo, Yan, Zhen, Fushinobu, Shinya, Kamada, Haruhiko, Kato, Hisanori, Hashidume, Tsutomu, Shimizu, Makoto, Sato, Ryuichiro
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Gene Regulation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4583009/
https://ncbi.nlm.nih.gov/pubmed/26272613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.645200
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