Using a prime and pull approach, lentivector vaccines expressing Ag85A induce immunogenicity but fail to induce protection against Mycobacterium bovis bacillus Calmette–Guérin challenge in mice

Although bacillus Calmette–Guérin (BCG) is an established vaccine with excellent efficacy against disseminated Mycobacterium tuberculosis infection in young children, efficacy in adults suffering from respiratory tuberculosis (TB) is suboptimal. Prime-boost viral vectored vaccines have been shown to...

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Опубликовано в: :Immunology
Главные авторы: Britton, Gary, MacDonald, Douglas C, Brown, Jeremy S, Collins, Mary K, Goodman, Anna L
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley & Sons, Ltd 2015
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Original Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582967/
https://ncbi.nlm.nih.gov/pubmed/26095282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imm.12498
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