Priming by DNA Immunization Augments Protective Efficacy of Mycobacterium bovis Bacille Calmette-Guerin against Tuberculosis

Sequential immunization with mycobacterial antigen Ag85B-expressing DNA and Mycobacterium bovis bacille Calmette-Guerin (BCG) was more effective than BCG immunization in protecting against Mycobacterium tuberculosis infection. Depletion of the CD8(+) T cells in the immunized mice impaired protection...

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Main Authors: Feng, Carl G., Palendira, Umaimainthan, Demangel, Caroline, Spratt, Joanne M., Malin, Adam S., Britton, Warwick J.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Microbial Immunity and Vaccines
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC98488/
https://ncbi.nlm.nih.gov/pubmed/11349095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.6.4174-4176.2001
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