Lung necrosis and neutrophils reflect common pathways of susceptibility to Mycobacterium tuberculosis in genetically diverse, immune-competent mice

Pulmonary tuberculosis (TB) is caused by Mycobacterium tuberculosis in susceptible humans. Here, we infected Diversity Outbred (DO) mice with ∼100 bacilli by aerosol to model responses in a highly heterogeneous population. Following infection, ‘supersusceptible’, ‘susceptible’ and ‘resistant’ phenot...

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Bibliographic Details
Published in:Dis Model Mech
Main Authors: Niazi, Muhammad K. K., Dhulekar, Nimit, Schmidt, Diane, Major, Samuel, Cooper, Rachel, Abeijon, Claudia, Gatti, Daniel M., Kramnik, Igor, Yener, Bulent, Gurcan, Metin, Beamer, Gillian
Format: Artigo
Language:Inglês
Published: The Company of Biologists 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582107/
https://ncbi.nlm.nih.gov/pubmed/26204894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.020867
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