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HIF1α deficiency reduces inflammation in a mouse model of proximal colon cancer
Hypoxia-inducible factor 1α (HIF1α) is a transcription factor that regulates the adaptation of cells to hypoxic microenvironments, for example inside solid tumours. Stabilisation of HIF1α can also occur in normoxic conditions in inflamed tissue or as a result of inactivating mutations in negative re...
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| Veröffentlicht in: | Dis Model Mech |
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| Hauptverfasser: | , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The Company of Biologists
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4582097/ https://ncbi.nlm.nih.gov/pubmed/26183215 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.019000 |
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