Sulindac activates NF-κB signaling in colon cancer cells

BACKGROUND: The non-steroidal anti-inflammatory drug (NSAID) sulindac has shown efficacy in preventing colorectal cancer. This potent anti-tumorigenic effect is mediated through multiple cellular pathways but is also accompanied by gastrointestinal side effects, such as colon inflammation. We have r...

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Main Authors: Mladenova, Dessislava, Pangon, Laurent, Currey, Nicola, Ng, Irvin, Musgrove, Elizabeth A, Grey, Shane T, Kohonen-Corish, Maija RJ
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2013
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Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3896984/
https://ncbi.nlm.nih.gov/pubmed/24083678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-11-73
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