Role of PI4K and PI3K-AKT in ERK1/2 activation by GnRH in the Pituitary Gonadotropes

The role of PI4K and PI3K-AKT in ERK1/2 activation by GnRH was examined. A relatively long preincubation (60 min) with wortmannin (10nM and 10μM), and LY294002 (10μM and 100μM) (doses known to inhibit PI3K and PI4K, respectively), were required to inhibit GnRH-and PMA-stimulated ERK1/2 activity in α...

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Publicado en:Mol Cell Endocrinol
Autores principales: Bar-Lev, Tali H., Harris, Dagan, Tomić, Melanija, Stojilkovic, Stanko, Blumenfeld, Zeev, Brown, Pamela, Seger, Rony, Naor, Zvi
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4582010/
https://ncbi.nlm.nih.gov/pubmed/26238084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2015.07.029
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