GnRH Induces ERK-Dependent Bleb Formation in Gonadotrope Cells, Involving Recruitment of Members of a GnRH Receptor-Associated Signalosome to the Blebs

We have previously described a signaling complex (signalosome) associated with the GnRH receptor (GnRHR). We now report that GnRH induces bleb formation in the gonadotrope-derived LβT2 cells. The blebs appear within ~2 min at a turnover rate of ~2–3 blebs/min and last for at least 90 min. Formation...

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Detalhes bibliográficos
Publicado no:Front Endocrinol (Lausanne)
Main Authors: Rahamim-Ben Navi, Liat, Tsukerman, Anna, Feldman, Alona, Melamed, Philippa, Tomić, Melanija, Stojilkovic, Stanko S., Boehm, Ulrich, Seger, Rony, Naor, Zvi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5454083/
https://ncbi.nlm.nih.gov/pubmed/28626446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fendo.2017.00113
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