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Cross-talk between carbon metabolism and the DNA damage response in S. cerevisiae
Yeast cells with DNA damage avoid respiration, presumably because products of oxidative metabolism can be harmful to DNA. We show that DNA damage inhibits the activity of the Snf1 (AMP-activated) protein kinase (AMPK), which activates expression of genes required for respiration. Glucose and DNA dam...
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| Publicado en: | Cell Rep |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2015
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4581987/ https://ncbi.nlm.nih.gov/pubmed/26344768 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.08.025 |
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