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Cross-talk between carbon metabolism and the DNA damage response in S. cerevisiae

Yeast cells with DNA damage avoid respiration, presumably because products of oxidative metabolism can be harmful to DNA. We show that DNA damage inhibits the activity of the Snf1 (AMP-activated) protein kinase (AMPK), which activates expression of genes required for respiration. Glucose and DNA dam...

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Détails bibliographiques
Publié dans:Cell Rep
Auteurs principaux: Simpson-Lavy, Kobi J., Bronstein, Alex, Kupiec, Martin, Johnston, Mark
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581987/
https://ncbi.nlm.nih.gov/pubmed/26344768
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2015.08.025
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