Molecular docking to identify associations between drugs and class I human leukocyte antigens for predicting idiosyncratic drug reactions

Idiosyncratic drug reactions (IDRs) are rare, somewhat dose-independent, patient-specific and hard to predict. Human leukocyte antigens (HLAs) are the major histocompatibility complex (MHC) in humans, are highly polymorphic and are associated with specific IDRs. Therefore, it is important to identif...

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Publicado en:Comb Chem High Throughput Screen
Autores principales: Luo, Heng, Du, Tingting, Zhou, Peng, Yang, Lun, Mei, Hu, Ng, Huiwen, Zhang, Wenqian, Shu, Mao, Tong, Weida, Shi, Leming, Mendrick, Donna L., Hong, Huixiao
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581727/
https://ncbi.nlm.nih.gov/pubmed/25747444
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