Designed biosynthesis of 25-methyl and 25-ethyl ivermectin with enhanced insecticidal activity by domain swap of avermectin polyketide synthase

BACKGROUND: Avermectin and milbemycin are important 16-membered macrolides that have been widely used as pesticides in agriculture. However, the wide use of these pesticides inevitably causes serious drug resistance, it is therefore imperative to develop new avermectin and milbemycin analogs. The bi...

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Vydáno v:Microb Cell Fact
Hlavní autoři: Zhang, Ji, Yan, Yi-Jun, An, Jing, Huang, Sheng-Xiong, Wang, Xiang-Jing, Xiang, Wen-Sheng
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4581413/
https://ncbi.nlm.nih.gov/pubmed/26400541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12934-015-0337-y
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