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Peripheral CD27(−)CD21(−) B-cells represent an exhausted lymphocyte population in hepatitis C cirrhosis()

Hepatitis C cirrhosis is associated with a profound disappearance of memory B-cells. We sought to determine if this loss is associated with the expansion of the CD27(−)CD21(−) tissue-like memory B-cells with features of B-cell exhaustion. To this end, we quantified the frequency of CD27(−) CD21(−) B...

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Pubblicato in:Clin Immunol
Autori principali: Doi, Hiroyoshi, Tanoue, Shiroh, Kaplan, David E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580910/
https://ncbi.nlm.nih.gov/pubmed/24434272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2013.12.001
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