Pharmacogenetic stimulation of cholinergic pedunculopontine neurons reverses motor deficits in a rat model of Parkinson’s disease

BACKGROUND: Patients with advanced Parkinson's disease (PD) often present with axial symptoms, including postural- and gait difficulties that respond poorly to dopaminergic agents. Although deep brain stimulation (DBS) of a highly heterogeneous brain structure, the pedunculopontine nucleus (PPN...

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Veröffentlicht in:Mol Neurodegener
Hauptverfasser: Pienaar, Ilse S., Gartside, Sarah E., Sharma, Puneet, De Paola, Vincenzo, Gretenkord, Sabine, Withers, Dominic, Elson, Joanna L., Dexter, David T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2015
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580350/
https://ncbi.nlm.nih.gov/pubmed/26394842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0044-5
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