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Replication-Competent Controlled Herpes Simplex Virus

We present the development and characterization of a replication-competent controlled herpes simplex virus 1 (HSV-1). Replication-essential ICP4 and ICP8 genes of HSV-1 wild-type strain 17syn+ were brought under the control of a dually responsive gene switch. The gene switch comprises (i) a transact...

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Détails bibliographiques
Publié dans:J Virol
Auteurs principaux: Bloom, David C., Feller, Joyce, McAnany, Peterjon, Vilaboa, Nuria, Voellmy, Richard
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4580158/
https://ncbi.nlm.nih.gov/pubmed/26269179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01667-15
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