Specific Histone Tail Modification and Not DNA Methylation Is a Determinant of Herpes Simplex Virus Type 1 Latent Gene Expression

During herpes simplex virus type 1 (HSV-1) latency, gene expression is tightly repressed except for the latency-associated transcript (LAT). The mechanistic basis for this repression is unknown, but its global nature suggests regulation by an epigenetic mechanism such as DNA methylation. Previous wo...

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Bibliographic Details
Main Authors: Kubat, Nicole J., Tran, Robert K., McAnany, Peterjon, Bloom, David C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Virus-Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC321404/
https://ncbi.nlm.nih.gov/pubmed/14722269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.3.1139-1149.2004
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