High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling

Direct reprogramming of fibroblasts into cardiomyocytes by forced expression of cardiomyogenic factors, GMT (GATA4, Mef2C, Tbx5) or GHMT (GATA4, Hand2, Mef2C, Tbx5), has recently been demonstrated, suggesting a novel therapeutic strategy for cardiac repair. However, current approaches are inefficien...

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Publicat a:Nat Commun
Autors principals: Zhao, Yuanbiao, Londono, Pilar, Cao, Yingqiong, Sharpe, Emily J., Proenza, Catherine, O'Rourke, Rebecca, Jones, Kenneth L., Jeong, Mark Y., Walker, Lori A., Buttrick, Peter M., McKinsey, Timothy A., Song, Kunhua
Format: Artigo
Idioma:Inglês
Publicat: Nature Pub. Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579788/
https://ncbi.nlm.nih.gov/pubmed/26354680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9243
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