dNP2 is a blood–brain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis

Central nervous system (CNS)-infiltrating effector T cells play critical roles in the development and progression of multiple sclerosis (MS). However, current drugs for MS are very limited due to the difficulty of delivering drugs into the CNS. Here we identify a cell-permeable peptide, dNP2, which...

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Published in:Nat Commun
Main Authors: Lim, Sangho, Kim, Won-Ju, Kim, Yeon-Ho, Lee, Sohee, Koo, Ja-Hyun, Lee, Jung-Ah, Yoon, Heeseok, Kim, Do-Hyun, Park, Hong-Jai, Kim, Hye-Mi, Lee, Hong-Gyun, Yun Kim, Ji, Lee, Jae-Ung, Hun Shin, Jae, Kyun Kim, Lark, Doh, Junsang, Kim, Hongtae, Lee, Sang-Kyou, Bothwell, Alfred L. M., Suh, Minah, Choi, Je-Min
Format: Artigo
Language:Inglês
Published: Nature Pub. Group 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579786/
https://ncbi.nlm.nih.gov/pubmed/26372309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms9244
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