Local Delivery of High-Dose Chondroitinase ABC in the Sub-Acute Stage Promotes Axonal Outgrowth and Functional Recovery after Complete Spinal Cord Transection

Chondroitin sulfate proteoglycans (CSPGs) are glial scar-associated molecules considered axonal regeneration inhibitors and can be digested by chondroitinase ABC (ChABC) to promote axonal regeneration after spinal cord injury (SCI). We previously demonstrated that intrathecal delivery of low-dose Ch...

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Udgivet i:PLoS One
Main Authors: Cheng, Chu-Hsun, Lin, Chi-Te, Lee, Meng-Jen, Tsai, May-Jywan, Huang, Wen-Hung, Huang, Ming-Chao, Lin, Yi-Lo, Chen, Ching-Jung, Huang, Wen-Cheng, Cheng, Henrich
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579094/
https://ncbi.nlm.nih.gov/pubmed/26393921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138705
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