Local Delivery of High-Dose Chondroitinase ABC in the Sub-Acute Stage Promotes Axonal Outgrowth and Functional Recovery after Complete Spinal Cord Transection

Chondroitin sulfate proteoglycans (CSPGs) are glial scar-associated molecules considered axonal regeneration inhibitors and can be digested by chondroitinase ABC (ChABC) to promote axonal regeneration after spinal cord injury (SCI). We previously demonstrated that intrathecal delivery of low-dose Ch...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Cheng, Chu-Hsun, Lin, Chi-Te, Lee, Meng-Jen, Tsai, May-Jywan, Huang, Wen-Hung, Huang, Ming-Chao, Lin, Yi-Lo, Chen, Ching-Jung, Huang, Wen-Cheng, Cheng, Henrich
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579094/
https://ncbi.nlm.nih.gov/pubmed/26393921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138705
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