Vitamin K3 (menadione) redox cycling inhibits cytochrome P450-mediated metabolism and inhibits parathion intoxication

Parathion, a widely used organophosphate insecticide, is considered a high priority chemical threat. Parathion toxicity is dependent on its metabolism by the cytochrome P450 system to paraoxon (diethyl 4-nitrophenyl phosphate), a cytotoxic metabolite. As an effective inhibitor of cholinesterases, pa...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Toxicol Appl Pharmacol
Hauptverfasser: Jan, Yi-Hua, Richardson, Jason R., Baker, Angela B., Mishin, Vladimir, Heck, Diane E., Laskin, Debra L., Laskin, Jeffrey D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4579064/
https://ncbi.nlm.nih.gov/pubmed/26212258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2015.07.023
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge