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Human Recombinant Cytochrome P450 Enzymes Display Distinct Hydrogen Peroxide Generating Activities During Substrate Independent NADPH Oxidase Reactions
Microsomal enzymes generate H(2)O(2) in the presence of NADPH. In this reaction, referred to as “oxidase” activity, H(2)O(2) is generated directly or indirectly via the formation of superoxide anion. In the presence of redox active transition metals, H(2)O(2) can form highly toxic hydroxyl radicals...
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| Publicado no: | Toxicol Sci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4271041/ https://ncbi.nlm.nih.gov/pubmed/25061110 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu133 |
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