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Human Recombinant Cytochrome P450 Enzymes Display Distinct Hydrogen Peroxide Generating Activities During Substrate Independent NADPH Oxidase Reactions

Microsomal enzymes generate H(2)O(2) in the presence of NADPH. In this reaction, referred to as “oxidase” activity, H(2)O(2) is generated directly or indirectly via the formation of superoxide anion. In the presence of redox active transition metals, H(2)O(2) can form highly toxic hydroxyl radicals...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Mishin, Vladimir, Heck, Diane E., Laskin, Debra L., Laskin, Jeffrey D.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
116
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271041/
https://ncbi.nlm.nih.gov/pubmed/25061110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu133
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