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Human Recombinant Cytochrome P450 Enzymes Display Distinct Hydrogen Peroxide Generating Activities During Substrate Independent NADPH Oxidase Reactions

Microsomal enzymes generate H(2)O(2) in the presence of NADPH. In this reaction, referred to as “oxidase” activity, H(2)O(2) is generated directly or indirectly via the formation of superoxide anion. In the presence of redox active transition metals, H(2)O(2) can form highly toxic hydroxyl radicals...

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Foilsithe in:Toxicol Sci
Main Authors: Mishin, Vladimir, Heck, Diane E., Laskin, Debra L., Laskin, Jeffrey D.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Oxford University Press 2014
Ábhair:
116
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4271041/
https://ncbi.nlm.nih.gov/pubmed/25061110
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfu133
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