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Inhibition of NADPH cytochrome P450 reductase by the model sulfur mustard vesicant 2-chloroethyl ethyl sulfide is associated with increased production of reactive oxygen species

Inhalation of vesicants including sulfur mustard can cause significant damage to the upper airways. This is the result of vesicant-induced modifications of proteins important in maintaining the integrity of the lung. Cytochrome P450’s are the major enzymes in the lung mediating detoxification of sul...

詳細記述

保存先:
書誌詳細
出版年:Toxicol Appl Pharmacol
主要な著者: Gray, Joshua P., Mishin, Vladimir, Heck, Diane E., Laskin, Debra L., Laskin, Jeffrey D.
フォーマット: Artigo
言語:Inglês
出版事項: 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4540603/
https://ncbi.nlm.nih.gov/pubmed/20561902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2010.05.015
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