Facilitated spinal neuropeptide signaling and upregulated inflammatory mediator expression contribute to postfracture nociceptive sensitization

Tibia fracture induces exaggerated substance P (SP) and calcitonin gene–related peptide (CGRP) signaling and neuropeptide-dependent nociceptive and inflammatory changes in the hind limbs of rats similar to those seen in complex regional pain syndrome. Inflammatory changes in the spinal cord contribu...

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Detalhes bibliográficos
Publicado no:Pain
Main Authors: Shi, Xiaoyou, Guo, Tian-Zhi, Wei, Tzuping, Li, Wen-Wu, Clark, David J., Kingery, Wade S.
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578973/
https://ncbi.nlm.nih.gov/pubmed/25932690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/j.pain.0000000000000204
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