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Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease

Chagas disease, caused by the protozoan parasite Trypanosoma cruzi (T. cruzi), is a life threatening global health problem with only two drugs available for treatment (benznidazole and nifurtimox), both having variable efficacy in the chronic stage of the disease and high rates of adverse drug react...

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Bibliografiske detaljer
Udgivet i:PLoS Negl Trop Dis
Main Authors: Riley, Jennifer, Brand, Stephen, Voice, Michael, Caballero, Ivan, Calvo, David, Read, Kevin D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578769/
https://ncbi.nlm.nih.gov/pubmed/26394211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pntd.0004014
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