Caspase-8 expression is predictive of tumour response to death receptor 5 agonist antibody in Ewing's sarcoma

BACKGROUND: Despite good initial response to chemotherapy, 30% of Ewing's sarcoma (EWS) patients with localised tumours develop recurrent disease, associated with poor prognosis. The aim of this study was to address this challenge by conducting preclinical evaluation of a death receptor targete...

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Detalhes bibliográficos
Publicado no:Br J Cancer
Main Authors: Kang, Zhigang, Goldstein, Seth D, Yu, Yunkai, Meltzer, Paul S, Loeb, David M, Cao, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4578089/
https://ncbi.nlm.nih.gov/pubmed/26291055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.298
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