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Drozitumab, a human antibody to death receptor 5, has potent anti-tumor activity against rhabdomyosarcoma with the expression of caspase-8 predictive of response

PURPOSE: Rhabdomyosarcoma (RMS) is a common pediatric soft-tissue tumor. In this study, we evaluated the efficacy and selectivity of drozitumab, a death receptor DR5-targeted therapeutic antibody, in RMS preclinical models. EXPERIMENTAL DESIGN: A panel of 11 RMS cell lines was used for in vitro stud...

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Detalhes bibliográficos
Main Authors: Kang, Zhigang, Chen, Jun-Jie, Yu, Yunkai, Li, Bo, Sun, Shi-Yong, Zhang, Baolin, Cao, Liang
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3096734/
https://ncbi.nlm.nih.gov/pubmed/21385927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2874
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