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Phosphine-Catalyzed Doubly Stereoconvergent γ-Additions of Racemic Heterocycles to Racemic Allenoates: The Catalytic Enantioselective Synthesis of Protected α,α-Disubstituted α-Amino Acid Derivatives

[Image: see text] Methods have recently been developed for the phosphine-catalyzed asymmetric γ-addition of nucleophiles to readily available allenoates and alkynoates to generate useful α,β-unsaturated carbonyl compounds that bear a stereogenic center in either the γ or the δ position (but not both...

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Bibliografiske detaljer
Udgivet i:J Am Chem Soc
Main Authors: Kalek, Marcin, Fu, Gregory C.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2015
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577964/
https://ncbi.nlm.nih.gov/pubmed/26192217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b05528
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