Brain endothelial TAK1 and NEMO safeguard the neurovascular unit

Inactivating mutations of the NF-κB essential modulator (NEMO), a key component of NF-κB signaling, cause the genetic disease incontinentia pigmenti (IP). This leads to severe neurological symptoms, but the mechanisms underlying brain involvement were unclear. Here, we show that selectively deleting...

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Publicado en:J Exp Med
Autores principales: Ridder, Dirk A., Wenzel, Jan, Müller, Kristin, Töllner, Kathrin, Tong, Xin-Kang, Assmann, Julian C., Stroobants, Stijn, Weber, Tobias, Niturad, Cristina, Fischer, Lisanne, Lembrich, Beate, Wolburg, Hartwig, Grand’Maison, Marilyn, Papadopoulos, Panayiota, Korpos, Eva, Truchetet, Francois, Rades, Dirk, Sorokin, Lydia M., Schmidt-Supprian, Marc, Bedell, Barry J., Pasparakis, Manolis, Balschun, Detlef, D’Hooge, Rudi, Löscher, Wolfgang, Hamel, Edith, Schwaninger, Markus
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2015
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577837/
https://ncbi.nlm.nih.gov/pubmed/26347470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20150165
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