Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system

Apelin and its G protein-coupled receptor (GPCR) have emerged as a key signalling pathway in the cardiovascular system. The peptide is a potent inotropic agent and vasodilator. Remarkably, a peptide, Elabela/Toddler, that has little sequence similarity to apelin, has been proposed as a second endoge...

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Bibliographic Details
Published in:Trends Pharmacol Sci
Main Authors: Yang, Peiran, Maguire, Janet J., Davenport, Anthony P.
Format: Artigo
Language:Inglês
Published: Published By Elsevier In Association With The International Union Of Pharmacology 2015
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4577653/
https://ncbi.nlm.nih.gov/pubmed/26143239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2015.06.002
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