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Integration of Signaling in the Kinome: Architecture and Regulation of the αC Helix
Eukaryotic protein kinases have evolved to be highly regulated and dynamic molecular switches that are typically kept in an inactive state and then activated in response to extracellular signals. The hallmark signature of an active kinase is a hydrophobic spine called the regulatory (R) spine, which...
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| Veröffentlicht in: | Biochim Biophys Acta |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4577442/ https://ncbi.nlm.nih.gov/pubmed/25891902 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbapap.2015.04.007 |
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