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TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity

The present paradigms of selective autophagy in mammalian cells cannot fully explain the specificity and selectivity of autophagic degradation. In this paper, we report that a subset of tripartite motif (TRIM) proteins act as specialized receptors for highly specific autophagy (precision autophagy)...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Kimura, Tomonori, Jain, Ashish, Choi, Seong Won, Mandell, Michael A., Schroder, Kate, Johansen, Terje, Deretic, Vojo
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576868/
https://ncbi.nlm.nih.gov/pubmed/26347139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201503023
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