Importance of Large Intestine in Regulating Bile Acids and Glucagon-Like Peptide-1 in Germ-Free Mice

It is known that 1) elevated serum bile acids (BAs) are associated with decreased body weight, 2) elevated glucagon-like peptide-1 (GLP-1) levels can decrease body weight, and 3) germ-free (GF) mice are resistant to diet-induced obesity. The purpose of this study was to test the hypothesis that a la...

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Опубликовано в: :Drug Metab Dispos
Главные авторы: Selwyn, Felcy Pavithra, Csanaky, Iván L., Zhang, Youcai, Klaassen, Curtis D.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576674/
https://ncbi.nlm.nih.gov/pubmed/26199423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.065276
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https://ncbi.nlm.nih.gov/pmc/articles/PMC4576674/
https://ncbi.nlm.nih.gov/pubmed/26199423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.115.065276