Developmental Regulation of Drug-Processing Genes in Livers of Germ-Free Mice

Very little is known about the effect of gut microbiota on the ontogeny of drug-processing genes (DPGs) in liver. In this study, livers were harvested from conventional (CV) and germ-free (GF) male and female mice from 1 to 90 days of age. RNA-Seq in livers of 90-day-old male mice showed that xenobi...

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Publié dans:Toxicol Sci
Auteurs principaux: Selwyn, Felcy Pavithra, Cheng, Sunny Lihua, Bammler, Theo K., Prasad, Bhagwat, Vrana, Marc, Klaassen, Curtis, Cui, Julia Yue
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
Sujets:
Differential Drug Metabolism in Germ-Free Mice
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4560037/
https://ncbi.nlm.nih.gov/pubmed/26032512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv110
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