The Prodrug 4-Chlorokynurenine Causes Ketamine-Like Antidepressant Effects, but Not Side Effects, by NMDA/Glycine(B)-Site Inhibition

Currently approved antidepressant drug treatment typically takes several weeks to be effective. The noncompetitive N-methyl-d-aspartate (NMDA) receptor antagonist ketamine has shown efficacy as a rapid-acting treatment of depression, but its use is associated with significant side effects. We assess...

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Detalles Bibliográficos
Publicado en:J Pharmacol Exp Ther
Main Authors: Zanos, Panos, Piantadosi, Sean C., Wu, Hui-Qiu, Pribut, Heather J., Dell, Matthew J., Can, Adem, Snodgrass, H. Ralph, Zarate, Carlos A., Schwarcz, Robert, Gould, Todd D.
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Behavioral Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576668/
https://ncbi.nlm.nih.gov/pubmed/26265321
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.115.225664
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