R-Baclofen Reverses a Social Behavior Deficit and Elevated Protein Synthesis in a Mouse Model of Fragile X Syndrome

BACKGROUND: Fragile X syndrome (FXS) is the most common known inherited form of intellectual disability and the single genomic cause of autism spectrum disorders. It is caused by the absence of a fragile X mental retardation gene (Fmr1) product, FMRP, an RNA-binding translation suppressor. Elevated...

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Bibliographic Details
Published in:Int J Neuropsychopharmacol
Main Authors: Qin, Mei, Huang, Tianjian, Kader, Michael, Krych, Leland, Xia, Zengyan, Burlin, Thomas, Zeidler, Zachary, Zhao, Tingrui, Smith, Carolyn B
Format: Artigo
Language:Inglês
Published: Oxford University Press 2015
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576516/
https://ncbi.nlm.nih.gov/pubmed/25820841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyv034
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