A Structural View of Negative Regulation of the Toll-like Receptor-Mediated Inflammatory Pathway

Even though the Toll-like receptor (TLR) pathway is integral to inflammatory defense mechanisms, its excessive signaling may be devastating. Cells have acquired a cascade of strategies to regulate TLR signaling by targeting protein-protein interactions, or ubiquitin chains, but the details of the in...

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Vydáno v:Biophys J
Hlavní autoři: Guven-Maiorov, Emine, Keskin, Ozlem, Gursoy, Attila, Nussinov, Ruth
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2015
Témata:
Proteins and Nucleic Acids
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576153/
https://ncbi.nlm.nih.gov/pubmed/26276688
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.06.048
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