In Vitro Virology Profile of Tenofovir Alafenamide, a Novel Oral Prodrug of Tenofovir with Improved Antiviral Activity Compared to That of Tenofovir Disoproxil Fumarate

Tenofovir alafenamide (TAF) is an investigational oral prodrug of the HIV-1 nucleotide reverse transcriptase inhibitor tenofovir (TFV). Tenofovir disoproxil fumarate (TDF) is another TFV prodrug, widely used for the treatment of HIV-1 infection. TAF is converted mostly intracellularly to TFV and, in...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Callebaut, Christian, Stepan, George, Tian, Yang, Miller, Michael D.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2015
Fag:
Antiviral Agents
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576064/
https://ncbi.nlm.nih.gov/pubmed/26149992
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01152-15
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