Characterization of HIV-1 Resistance to Tenofovir Alafenamide In Vitro

Tenofovir alafenamide (TAF) is an investigational prodrug of the HIV-1 nucleotide reverse transcriptase (RT) inhibitor (NtRTI) tenofovir (TFV), with improved potency and drug delivery properties over the current prodrug, tenofovir disoproxil fumarate (TDF). TAF is currently in phase 3 clinical studi...

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Bibliographic Details
Published in:Antimicrob Agents Chemother
Main Authors: Margot, Nicolas A., Johnson, Audun, Miller, Michael D., Callebaut, Christian
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2015
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576099/
https://ncbi.nlm.nih.gov/pubmed/26149983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01151-15
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