Pharmacokinetic Modeling of Lamivudine and Zidovudine Triphosphates Predicts Differential Pharmacokinetics in Seminal Mononuclear Cells and Peripheral Blood Mononuclear Cells

The male genital tract is a potential site of viral persistence. Therefore, adequate concentrations of antiretrovirals are required to eliminate HIV replication in the genital tract. Despite higher zidovudine (ZDV) and lamivudine (3TC) concentrations in seminal plasma (SP) than in blood plasma (BP)...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Dumond, Julie B., Yang, Kuo H., Kendrick, Racheal, Reddy, Y. Sunila, Kashuba, Angela D. M., Troiani, Luigi, Bridges, Arlene S., Fiscus, Susan A., Forrest, Alan, Cohen, Myron S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2015
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576057/
https://ncbi.nlm.nih.gov/pubmed/26239974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01148-15
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