Pharmacokinetic Modeling of Lamivudine and Zidovudine Triphosphates Predicts Differential Pharmacokinetics in Seminal Mononuclear Cells and Peripheral Blood Mononuclear Cells

The male genital tract is a potential site of viral persistence. Therefore, adequate concentrations of antiretrovirals are required to eliminate HIV replication in the genital tract. Despite higher zidovudine (ZDV) and lamivudine (3TC) concentrations in seminal plasma (SP) than in blood plasma (BP)...

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Dumond, Julie B., Yang, Kuo H., Kendrick, Racheal, Reddy, Y. Sunila, Kashuba, Angela D. M., Troiani, Luigi, Bridges, Arlene S., Fiscus, Susan A., Forrest, Alan, Cohen, Myron S.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2015
Konular:
Antiviral Agents
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4576057/
https://ncbi.nlm.nih.gov/pubmed/26239974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01148-15
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