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The replication checkpoint prevents two types of fork collapse without regulating replisome stability
The ATR replication checkpoint ensures that stalled forks remain stable when replisome movement is impeded. Using an improved iPOND protocol combined with SILAC mass spectrometry, we characterized human replisome dynamics in response to fork stalling. Our data provide a quantitative picture of the r...
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| Опубликовано в: : | Mol Cell |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2015
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4575883/ https://ncbi.nlm.nih.gov/pubmed/26365379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.07.030 |
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