Decreased T(FR)/T(FH) ratio in SIV-infected rhesus macaques may contribute to accumulation of T(FH) cells in chronic infection

T follicular helper cells (T(FH)) are critical for the development and maintenance of germinal centers (GC) and humoral immune responses. During chronic HIV/SIV infection T(FH) accumulate, possibly as a result of antigen persistence. The HIV/SIV-associated T(FH) expansion may also reflect lack of re...

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Veröffentlicht in:J Immunol
Hauptverfasser: Chowdhury, Ankita, Estrada Del Rio, Perla Maria, Tharp, Greg K, Trible, Ronald P, Amara, Rama R, Chahroudi, Ann, Reyes-Teran, Gustavo, Bosinger, Steven E., Silvestri, Guido
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575868/
https://ncbi.nlm.nih.gov/pubmed/26297764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402701
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