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Solid-phase synthesis of short α-helices stabilized by the hydrogen bond surrogate approach
Stabilized α-helices and nonpeptidic helix mimetics have emerged as powerful molecular scaffolds for the discovery of protein–protein interaction inhibitors. Protein-protein interactions often involve large contact areas, which are often difficult for small molecules to target with high specificity....
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| Publicado en: | Nat Protoc |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2010
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4575786/ https://ncbi.nlm.nih.gov/pubmed/21030960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nprot.2010.146 |
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