Cytosolic nuclease TREX1 regulates oligosaccharyltransferase activity independent of nuclease activity to suppress immune activation

TREX1 is an endoplasmic reticulum (ER)-associated negative regulator of innate immunity. TREX1 mutations are associated with autoimmune and autoinflammatory diseases. Biallelic mutations abrogating DNase activity cause autoimmunity by allowing immunogenic self-DNA to accumulate, but it is unknown ho...

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Veröffentlicht in:Immunity
Hauptverfasser: Hasan, Maroof, Fermaintt, Charles S., Gao, Ningguo, Sakai, Tomomi, Miyazaki, Takuya, Jiang, Sixin, Li, Quan-Zhen, Atkinson, John P., Morse, Herbert C., Lehrman, Mark A., Yan, Nan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575271/
https://ncbi.nlm.nih.gov/pubmed/26320659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2015.07.022
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