Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex

TREX1 mutations are associated with several auto-immune and inflammatory diseases. The N-terminal DNase domain of TREX1 is important for preventing self-DNA from activating the interferon response. The C terminus of TREX1 is required for ER localization and regulation of oligosacchariyltransferase (...

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Vydáno v:Cell Rep
Hlavní autoři: Kucej, Martin, Fermaintt, Charles S., Yang, Kun, Irizarry-Caro, Ricardo A., Yan, Nan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703050/
https://ncbi.nlm.nih.gov/pubmed/28297665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.02.051
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