Evidence for Reduced Drug Susceptibility without Emergence of Major Protease Mutations following Protease Inhibitor Monotherapy Failure in the SARA Trial

BACKGROUND: Major protease mutations are rarely observed following failure with protease inhibitors (PI), and other viral determinants of failure to PI are poorly understood. We therefore characterized Gag-Protease phenotypic susceptibility in subtype A and D viruses circulating in East Africa follo...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sutherland, Katherine A., Parry, Chris M., McCormick, Adele, Kapaata, Anne, Lyagoba, Fred, Kaleebu, Pontiano, Gilks, Charles F., Goodall, Ruth, Spyer, Moira, Kityo, Cissy, Pillay, Deenan, Gupta, Ravindra K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575205/
https://ncbi.nlm.nih.gov/pubmed/26382239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0137834
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