Impact of the N348I Mutation in HIV-1 Reverse Transcriptase on Nonnucleoside Reverse Transcriptase Inhibitor Resistance in Non-Subtype B HIV-1

We investigated the effect of N348I alone and with M184V on nonnucleoside reverse transcriptase inhibitor (NNRTI) drug susceptibility and replicative capacity in B and non-B HIV-1 isolates. N348I reduced the susceptibility to all NNRTI drugs across subtypes. The replication capacity of all viruses i...

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Detalhes bibliográficos
Main Authors: McCormick, Adele L., Parry, Chris M., Crombe, Anne, Goodall, Ruth L., Gupta, Ravindra K., Kaleebu, Pontiano, Kityo, Cissy, Chirara, Michael, Towers, Greg J., Pillay, Deenan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2011
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3067126/
https://ncbi.nlm.nih.gov/pubmed/21282419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01197-10
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