Cryptococcus neoformans Infection in Mice Lacking Type I Interferon Signaling Leads to Increased Fungal Clearance and IL-4-Dependent Mucin Production in the Lungs

Type I interferons (IFNs) are secreted by many cell types upon stimulation via pattern recognition receptors and bind to IFN-α/β receptor (IFNAR), which is composed of IFNAR1 and IFNAR2. Although type I IFNs are well known as anti-viral cytokines, limited information is available on their role durin...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Sato, Ko, Yamamoto, Hideki, Nomura, Toshiki, Matsumoto, Ikumi, Miyasaka, Tomomitsu, Zong, Tong, Kanno, Emi, Uno, Kazuko, Ishii, Keiko, Kawakami, Kazuyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4575107/
https://ncbi.nlm.nih.gov/pubmed/26384031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0138291
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