The effect of atorvastatin treatment on serum oxysterol concentrations and cytochrome P450 3A4 activity

AIMS: Atorvastatin is known to both inhibit and induce the cytochrome P450 3A4 (CYP3A4) enzyme in vitro. Some clinical studies indicate that atorvastatin inhibits CYP3A4 but there are no well-controlled longer term studies that could evaluate the inducing effect of atorvastatin. We aimed to determin...

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Dades bibliogràfiques
Publicat a:Br J Clin Pharmacol
Autors principals: Hukkanen, Janne, Puurunen, Johanna, Hyötyläinen, Tuulia, Savolainen, Markku J, Ruokonen, Aimo, Morin-Papunen, Laure, Orešič, Matej, Piltonen, Terhi, Tapanainen, Juha S
Format: Artigo
Idioma:Inglês
Publicat: John Wiley & Sons, Ltd 2015
Matèries:
Clinical Trials
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574832/
https://ncbi.nlm.nih.gov/pubmed/26095142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12701
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