Inhibitory FcγRIIb-Mediated Soluble Antigen Clearance from Plasma by a pH-Dependent Antigen-Binding Antibody and Its Enhancement by Fc Engineering

Fc engineering can modulate the Fc–FcγR interaction and thus enhance the potency of Abs that target membrane-bound Ags, but it has not been applied to Abs that target soluble Ags. In this study, we revealed a previously unknown function of inhibitory FcγRII in vivo and, using an Ab that binds to Ag...

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Dettagli Bibliografici
Pubblicato in:J Immunol
Autori principali: Iwayanagi, Yuki, Igawa, Tomoyuki, Maeda, Atsuhiko, Haraya, Kenta, Wada, Naoko A., Shibahara, Norihito, Ohmine, Ken, Nambu, Takeru, Nakamura, Genki, Mimoto, Futa, Katada, Hitoshi, Ito, Shunsuke, Tachibana, Tatsuhiko, Jishage, Kou-ichi, Hattori, Kunihiro
Natura: Artigo
Lingua:Inglês
Pubblicazione: AAI 2015
Soggetti:
Immunotherapy and Vaccines
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574519/
https://ncbi.nlm.nih.gov/pubmed/26320252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401470
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